I'm at a loss We had same issues. I have been giving my lab puppy (6 months old now) Simparica Trio since October. That night he seemed a little uncomfortable, unable to sleep, and I didnt think anything of it. Shame on you! We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects. Possible Side Effects. Zoetis.com.au; Privacy Policy This links to a pdf file; Terms of Use This links to a pdf file I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. That trip cost $400 and the result was he needed Simparica flea treatment. Anything I can do for him? My 9 month old puppy started acting very lethargic after taking simparica trio. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. All they did was give me a pill in a bag with possible side effects of vomiting or diarrhea. So I did. If this was our children and you went to your doctor for a shot, and the Dr. said "don't worry, only 1% of kids get seizures or other problems from this shot, we wouldn't stand for it. Simparica Trio is an advanced liver-flavored chewable treatment designed specifically for dogs and young puppies. Vet thought was inner ear infection now thinking otherwise. I wish I could get it out of her system. Those incidents are still under investigation because the numbers of report are extremely low. How common are Simparica side effects? Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. I have been feeding her some white rice hoping it improves. CET Enzymatic Oral Hygiene Chews for Dogs. Im switching back to the protection he used before Simparica Trio. Been also very lethargic not wanting to get out of bed. My wife and I didn't understand why. after a few months of this i decided to go back to Sentinel and Bravecto. All they care about is the money and not the animal. In other words, they can make it easier to have a seizure in susceptible dogs. Simparica may show slide side effects in a few dogs like tremors, unsteadiness, and/or seizures but else it is Tested and FDA approved suits to 90% of dogs. Will not be using this treatment again!!! There is a petition in Australia to have this drug banned through change.org, which I've signed. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. The excerpts below from the manufacturers' Prescribing . Not to worry you, and I hope yours is different outcome! For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. Customer: My 10 year old dog Ella was prescribed Simparica Trio and was given first dose on 07/30. Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. Are there any side effects to Simparica Trio? Reading all these similar cases cant figure out how the hell this crap is still being prescribed. I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. Sunday, he was lethargic and refused to eat. How do I get this out of his system and what are you using instead? These are classic neurological symptoms, exactly what our Pickles had before she passed. They were good to deal with. Is it just me or does it seem like everyone is in this together? Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. No way I will ever give it to her again. org to have this poison recalled. Call the FDA. Please anyone let me know if there is a class action law suit or where we can start one? I called my Vet and waited all day for them to call back, useless. They must get some kind of monetary bonus for only selling Simparica. It has been 20 days since I gave her the prescribed dose of Simparica. Really? Was hospitalized for 2 1/2 days. Sorry but keeping it caged due to a suspected side effect is is uncalled for. Decreased conscious proprioception. Being in CT where Lyme disease is high it's a relief to have top shelf protection. Head bobbling and hind legs unable to support her - as if she were really drunk. I have always used topical tx. All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. The personality change is what has me most concerned too. Our baby isnt the same at all since his one and only dose of Simparica. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. This is whats happening to our pup, can you please tell me how long it lasted? With the March 1 dose, on that day, I noticed him seeming to be very fearful and flinching on several occasions. He just isnt himself. I to also gave my best friend Simparica as recommended by the vet. It was the first time she had taken Simparica. My Labradoodle had extreme diarrhea last night. Really angry this drug is on the market and pushed by many vets. Even when asked to go for a car ride he didn't respond. The reaction lasted less than 12 hours. I will post an update 7 days later. Vet says garlic doesn't work and obviously it didn't because he shaved a little of dogs fur and put it on a paper towels and it was full of fleas.The vet gives me Simpirica-ok fleas are dropping off him like crazy. When he lays in the sun you can see the bumps under his skin. The vet recognized immediately that she was in severe neurogical distress. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. She seems to have aged five years since T-Day. Then he starts scratching and as time goes on he seemed like something was wrong. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. Gave our pup of 10 years the Simparica Trio as suggested by our vet 1 week ago instead of the Simparica and Interceptor he had been on for 7 years with no problems. And for those who have lost their fur babies I am so sorry for your lost. She has been on it for 6 months. Gave my 12 year old labradoodle simpatico just before going to my sons for T-Day dinner. It's unique because it kills more types of parasites than any other combination product available to date. . I took him back to the vet and explained my concern that it was from the Simparica Trio and they didn't seem concerned that it was the issue. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. He seems sometimes anxious and is sensitive to noise outside. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. He had full wellness exam three ago and was in perfect shape. Can my dog still get Lyme disease from a tick that was in him. This was the only thing we changed, I am convinced this is what did it to her. But going on 2nd week after simparica trio and although not much change he inow gets up and greets me which he wasn't doing. Vets have told us repeatedly that it can't be the medication. It's only available with a prescription from your veterinarian, so you . She started it on 7/22. When it came time to pick the right product for my own dog, I opted for Simparica Trio. I feel so bad ,my 8weeks cockerspaniel hasnt been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. We nurses him back into a happy healthy puppy and now this. He seems dehydrated. Sold as 1 Month, 3 Month or 6 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs. Just gave my baby her first dose. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. Instead it has become a world of greed. Barely eats, but is drinking lots of water. RELATED: What You Need to Know About the Lyme Vaccine for Dogs. I'm so scared. No more itching but covered in same scabs. My dog is on a "health care plan" with my vet. I went to zoetis and Expressed my views and they said the FDA report meant nothing and it was in America. A couple of weeks later she had lost weight from not eating. My aunt gave her 5.5-kg, 13-year-old female shih tzu the first dose of Simparica and she has never been the same as she shows symptoms of cardiopulmonary illness: lethargy, loss of appetite, vomit, coughing, seizure and excessive drinking. Now her dog is very sick and she has to take the dog to the vet every day in the past week. Stay safe! Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. Some years back my husband gave vet approved & sold oral flea/tic medication to each of our 2 Standard Poodles. Very small sample - many deformities, stillborn. The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. Then I gave it to her again the 3rd month and the same thing happened. He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. If so how long did it take? Lethargic and confused. I'm so sorry. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. I never missed a day. Its been 3 months and she continues to have them. But he had a terrifying seizure when I was out walking him on December 26, 2020 with no previous known history (he is rescue I've had since he was 2). It's been a little over two months since her last dose and feel certain that is what almost killed her. With Entyce she is getting her appetite back and seems a little better. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). Then she started having tremors. They are also drinking more than normal. All is good! So I started searching and came across this blog and my heart just sank. We are currently going through this with our nine year old dachshund. Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. Simparica is good at killing contagious parasites that cause mange and scabies. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. And since then has had diarrhea and loose poop. Did anyone see any signs of improvement in their dogs? I argued with the vet that this is poison and she said why would I give your dog poison? My dog is currently in an emergency hospital in Chicago with my daughter. Then the following week 1 pill every other day . The very next day he had diarrhea, and had it for 6 days. She has what is called knuckling. Next day, he was suddenly 1000% worse, would not touch food, could not move. She has been on our property for four year and has survived everything. I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. I suppose with any drug, during trials, there will be some who have side effects ranging from negligible to life threatening. Just gave 3yr old OES first dose yesterday (her half sister got one too) and today she has uncontrolled urination. And both of my other labs, basically house dogs, ended up with a droopy left eye. I will never give him this drug again. Very common in: Dogs of any age, breed, or gender can experience vomiting. I dont know what to do to get this out of their system?? So far, the cost of diagnostic tests are about $700. She has been diagnosed with thyroid problems and myocarditis. How old was your pup? She was riddled with parasites when she was found as a stray, and then treated for heartworm disease just before I adopted her. This is because it doesn't kill adult heartworms. This junk needs to be pulled from the market. Seems like it was directly related to the medication. After reading all these posts that sound so similar to what we are going through. You can do this by reporting to the drugs manufacturers, who are required to report this information to the FDA, or by submitting a report directly to the FDA. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. And how do we get the word out to everyone? Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. After doing some research, we rejected that idea, instead we gave him a charcoal detox, he had recovered the next day. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. Im certain that its the simparica. Thursday morning was an awful beginning of the day for our boy. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. I gave my sweet little toy poodle Simpaica today, and one hour later this poor dog went from happy and healthy to having a terrible seizure. You don't think I'm going to continue with this poison. Wow. She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). I sure hope we don't have ongoing problems. Doing better now, 2 days later. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. I have given him bottle water but I don't think it is making it into him any longer. Im beside myself with guilt and fear. Your pets condition worsens or does not improve with treatment, You have additional questions or concerns about the use of Simparica or Simparica Trio. I never saw a flea because he has a very thick coat. I am also going to contact the vet who gave it to me and tell him all this stuff. Once she is completely healed I am putting her back on those. She is absolutely miserable and we're hoping she makes it. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. She didn't make it to the next day and died overnight. We took him to vet and they gave nausea meds and kept him overnight. I am up writing this 4 a.m. since our Lambchop is too restless to sleep! I gave this to my #3. He has trouble raising his leg to urinate. He already has canine dementia on and off. They would clear up after a round of antibiotics but would return the next month. How is your dog doing? She seems so much happier in herself but until she comes off the keppra completely I wont know if it's a reversible problem. By Sunday he is having liquid diarrhea! She was shaking like she was freezing. Gave my 28lb German Spitz her monthly prescibed dose of Simparica. She had a beautiful coat of fur. How long did it last with your dog? What are the side effects of Simparica Trio Chewable Tablets for Dogs? She has good days and bad days but she is far from the dog she use to be. Good luck. Im seeing an improvement in my dog, and am crossing fingers that this continues! Our 3 mo.old Boston Terrier, 10 lbs, had her first dose of Simparaco yesterday. My poor baby! He collapsed & went limp in my arms . Dr said either Simparica (best case scenario), GOLPP or brain tumor. Went to a different vet, within minutes he found a large mass on my Poms abdomen. Our dog was killed by this poison within 15 hours after taking one dose. Gave Simparica to my dog yesterday. My dog (6 years old) has been using monthly Simparica since I got him. We are now back to regular vet with bloodwork every two weeks and still on meds and diarrhea but not as bad. During this period coincidentally I have noticed a change in his behaviour. Our two year old dog took the same thing and thank god she has no symptoms. Just gave this to my 2 year old 77 lb boxer 5 hours ago and I'm SCARED! Shame on me for trusting the doctors that shrug off their responsibilities to the office girls for one thing. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Side effects are uncommon, but may occur in some cases. They have become so bad that she cries and whimpers any time she is laying down. I gave my 1 year old collie cross Simparica flea and tick medication. If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. Does any one think this could be a reaction to Simparico Trio? So now after $90.00 spent on three pills this month, I decide to look up the answers myself. Im so angry at these drug companies and vets for selling this crap. Im switching back to the old stuff. PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs), 6 Doses. It's only available with a prescription from your veterinarian, so you cannot get it over-the-counter. I've sent this thread and loads of other information to my vet and zoetis. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. The doctor did blood work and gave him steroids and said to watch him carefully for the next few days. Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. So the next day was Saturday , me & my husband got up early . Did you do this yourself or let the vet? The next day she had diarrhea. Simparica Trio contains three active ingredients . Now I am terrified for his well being. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. Will never use again. Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. Simparica has possibly shown no severe side effects that may concern the health of dogs. He could not hold down any food or water. The same thing possibly is happening to my 9 month old Boxador. Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. While veterinarians often prescribe medications for off-label uses, your veterinarian will determine whether Simparica is right for your pet. Last month she had diarrhea and it lasted 7 days. I let him back in the bedroom yesterday all went well, then this morning I woke to him peeing in the floor again. . Im trying to understand how. His skin became itchy and his eyes were too. I have been telling everyone not to give this to their furry ones!!!!!!!! Used my own intuition and knowledge to make a good choice for my pet .good luck to everyone one here ! The company will not cover any products purchased through sites like Chewy or 1-800-Pet-Meds because they cannot be tracked to ensure they're legitimate and properly stored/handled (and due to the company's stance on product diversion). I'll continue to watch her. After the ER visit and a visit with our regular vet today, they concluded he is having neurological issues and that is why he cannot walk. Fortunately, no seizures but dark yellow diarrhea and puppy has been drinking water like crazy and peeing even while asleep. we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. She will never have this again, I can assure you! All the swelling went down immediately and the itching went away too. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fidos digestive tract, rather than his nervous system. He has been resting most of the day so far, thankfully no seizures.. but I promise I will not be giving him the other 2 doses I got from the vet after reading all of the experiences everyone else has had with their animals. No more of this med! Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. Its crazy to think they dont recover and can die in a few months. Side effects with Simparica are not common. She wanted me to monitor him carefully and wait to see how he did on his next dose of Simparica before continuing to prescribe it. He is fully housebroken and just had a running stool accident in the house. Doubtful our dog will be given Simparica again. corgi lying in grass next to woman's feet. Most of us dog parents use some form of heartworm prevention for our dogs. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. She is still eating but she is drinking more water. I hope it is better. The vet suggested this medication for my 9+ yr old English Bulldog. Hi i have only had my pup for about a week and a half i took him to vet and asked what would be safe to use since my pup is only about 11weeks old and weighs 4pds (prob less today) i gave him this medicine last nite and wish i would have seen this post sooner Now i pray he makes it thru the night. The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. So sorry you are having to go through this! I hope yours is an isolated incident! What scared me and caused me to start doing some more research is while drinking he stops and acts as if he has a lot of peanut butter in his mouth. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. Hello! Does anyone know of anything we can give her to help get this out of her system? Simparica may also cause the following side effects: Vomiting Diarrhea Lethargy Contact your veterinarian if your dog experiences any side effects as a result of taking Simparica. I'm kicking myself I didn't research this drug. Hi how is your pup now? I also changed him over to a raw diet a few weeks ago too have taken him off of this again to see if raw diet is causing it. I feel like this drug was pushed by my vet tech and veterinarian. I'm besides myself. If anyone wants to write or call to complain to the company I have all the details. Daily Paws is part of the Meredith National Digital Network. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. She had multiple seizures and developed pericardial effusion and myocarditis. I wish I had read these comments before giving this to my Frenchie. This seemed like perfect treatment 3 in 1 but at what cost? I will be discontinuing the medication. Our guy is having pain and is showing arthritic symptoms. By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. Only some dogs show this symptom. The vet said not to give it. Has anyone had a dermatitis issue as a result of Simparica? Hope your pup is doing better!! She falls when she runs and when going up and down stairs. Do not give extra or double doses. I thought right away it must be the new meds! I switched all three of my dogs to simparica trio and ironically my one that is a simi feral h/w+ hound disappeared. I am sorry you are going through this! I check this thread regularly and Im sooo grateful to all who wrote. We are already close to $2000 in Vet bills not counting the poison we bought her. My vet recommended this for my Scooby he justed turned 8 on July 4 and had to take him to vet because of fleas since Monday when he got his first treatment of simparica he's been momping around the house and not eating his food. I took him to the ER they checked his vitals and sent me home. After reading all your entries, i'm thrilled i chose to take her off of it. In addition to the tremors, have you noticed any . My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. Took a dose of simparica trio.second rose in second month.dog is having tremors. My Jack Russell Terrier has taken Simparica Trio for several months. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. They both got similar issues and this was the only thing they both did. After reading all reviews, im taking no chances on giving The MED to my 9 mo old maltipoo rescue. The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. (toy aussie & corgi). Sorry to hear about this happening to so many. Advised her to put a big note on our account that she is never to have this again. Also I read on Dr Mercola site that heartworms is in the dogs blood not the digestive track and garlic won't work. It seemed impossible that our boy could age years in literally 3 days. The seizure has finally stopped and he seems to be sleeping peacefully. He is very friendly with other people and pets and never had an issue in that regard. But anyways - the other night , his feet collapsed from under him & he fainted . This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. Today, he wouldn't eat or drink any water. Our Vet suggested Simparica Trio! However, some dog parents prefer to use separate products. The vet insisted it was not from the Simparica Trio. Gave my dogs simparica and they both have lost their appetite! Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. 'S only available with a prescription from your veterinarian will determine whether Simparica right... 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Of it eating but she is absolutely miserable and we 're hoping she makes it medicine as our doctor n't... And he seems sometimes anxious and is drinking lots of water grass next to woman 's feet never had issue. This stuff my one that is a simi feral h/w+ hound disappeared im no! Whether Simparica is right for your lost anyone see any signs of improvement in my is. Away eventually to worry you, and seizures him all this stuff he was and.